Transposition of the Great Arteries

Transposition of the Great Arteries


There are two separatecirculation:

The aorta is connected to right ventriclereceiving deoxygenated blood

The pulmonary artery is connected to the leftventricle receiving oxygenated  

blood from the lungs

These children are cyanosed and this defect isincompatible with life unless

there are separate defects to allow mixing ofblood (ASD, VSD or PDA)


Aetiology:                     Unknown


Symptoms:                   Cyanosis


Signs:                             Cyanosisat birth or presents with duct closure


Investigations:          Antenatalultrasound: Antenatal diagnosis may be made

ECG: Often normal

Chest X-Ray: Classical ‘egg on its side’ appearance of the heart shadow

Echo: To assess for structural abnormality and confirmdiagnosis


Treatment:                  Medical: Resuscitation and prostaglandins keep the ductusarteriosus patent

Surgical: Balloon atrial septostomy isrequired to allow mixing of the blood.  

Definitive treatment is arterial switch operation,which is carried out

in the first 2 weeks of life


Complications:          Arrhythmias,heart failure and infective endocarditis


Prognosis:                    Conditionis fatal unless treated.






Rectangle: Rounded Corners: NOTE FOR PUBLISHERS – 

Diagram of heart showing features of Transposition Of The Great Arteries with labels showing Aorta arising from right ventricle, pulmonary artery arising from left ventricle and PDA, ASD or VSD














Figure 1.20 Transposition Of The Great Arteries

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