IgA Nephropathy

IgA Nephropathy

Pathology:                    Depositionof IgA antibodies within the kidney leading to an immune reaction.


Aetiology:                     Unknownaetiology


Symptoms:                   Oliguria,peripheral oedema, Henoch-Schonlein purpura (non-blanching purpuric rash overlegs and buttocks, abdominal pains can also be present)


Signs:                              Hypertension,microscopic haematuria, proteinuria are the commonest findings


Investigations:          Bloods: Serum IgA, U&E – to monitorrenal function

MSU: Urine dipstick and protein: creatinine ratio,

Renal Biopsy: Definitive investigation showing IgA and C3deposits in renal



Treatment:                  Medical: Steroids, Immunosuppressants, ACEinhibitors


Complications:          Hypertensionand end stage renal failure


Prognosis:                    Agradual deterioration in renal function over many years with about a third developingend stage renal failure


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