Idiopathic Thrombocytopaenic Purpura

Idiopathic Thrombocytopaenic Purpura

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Antibody mediated destruction of megakaryocytes and platelets is the primary pathology of this condition.


The exact cause of this pathology is largely unknown, though it is often preceded by a viral infection in children.


  • Easy bruising
  • Menorrhagia (abnormally heavy menstrual bleeding)
  • Epistaxis (nosebleed)
  • Prolonged bleeding


Purpura (spontaneous discoloration of the skin caused by tiny blood vessel hemorrhages)


  • Bloods: A full blood count (FBC) will show a decreased platelet count, while the clotting screen should be normal.
  • Blood Film: Giant platelets may be observed.
  • Bone Marrow Biopsy: The number of megakaryocytes may be normal or increased.


  • Medical: If platelet count is <30 x109/L, steroids or immunosuppression therapy should be considered.
  • Surgical: Splenectomy is also an option.


Life-threatening bleeding may occur, and risk of life-threatening infections may arise following splenectomy or immunosuppression.


The prognosis for this condition is good if treated early.

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