Pathology: Endothelialdamage triggers deposition of fibrin, which damages passing red blood cellscausing:
Triad of:AKI, thrombocytopenia and haemolysis with red cell fragmentation
Aetiology: Post-infection:classically E. Coli 0157:H7 or Shigella dysenteriae
Symptoms: Haematuria, bloody diarrhoea, vomiting,abdominal pain, oliguria, fatigue
Signs: Pallor, petechiae, hypertension
Investigations: Bloods: FBC, U&E, Clotting, Bloodfilm
Urine: Haematuria
Stool Culture: Assess for bacterialinfection
Treatment: Supportive: IVI fluids, dialysis
Complications: CRF,hypertension
Prognosis: 5% mortality
