Goodpasture’s Syndrome

Goodpasture’s Syndrome

Pathology:                    Autoimmunecondition in which anti-glomerular basement membrane (anti-GBM) antibodies bindto alpha-3 chains of type IV collagen found in alveolar and glomerular basementmembranes causing glomerulonephritis and pneumonitis


Aetiology:                     Unknown aetiology but occurs following viral infection


Symptoms:                   Haemoptysis,shortness of breath, lethargy, nausea, dry cough, peripheral oedema


Signs:                              Hypertension, microscopic haematuria,proteinuria, haemoptysis


Investigations:          Bloods: FBC and anti-GBM antibodies

                                          Chest X-Ray: To assess for pulmonaryhaemhorrhage or infection

                                          Biopsy:Renal or lungbiopsy is diagnostic; renal biopsy shows cresenteric



Treatment:                  Medical: Plasma exchange – to remove antibodies and Immunosuppression:



Complications:          End stage renal failure, pulmonary haemorrhage,infections secondary to the immunosuppressive treatment can also be lifethreatening.


Prognosis:                    Depends on the initial renal function and extent of lung involvement andspeed of appropriate treatment so prompt diagnosis is key.

Join Shiken For FREE

Gumbo Study Buddy

Explore More Subject Explanations

Try Shiken Premium
for Free

14-day free trial. Cancel anytime.
Get Started
The first 14 days are on us
96% of learners report x2 faster learning
Free hands-on onboarding & support
Cancel Anytime