Churg-Strauss Disease

Churg-Strauss Disease

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Pathology affects small to medium sized vessels and is characterized by necrotising granuloma, which affects the vessels of the lungs, gastrointestinal (GI) tract, and peripheral nerves.


This pathology is often associated with perinuclear antineutrophil cytoplasmic antibody (pANCA).


  • Chest tightness
  • Wheeze
  • Shortness of breath
  • Sinusitis


The condition has 3 distinct stages:

  • Sinusitis and onset of allergies
  • Onset of acute asthma
  • Systemic involvement including skin purpura, GI upset, and peripheral neuropathy


  • Full blood count (FBC) which shows eosinophilia, pANCA, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR)
  • Imaging such as chest X-ray which shows eosinophilic lung deposits


Medical treatment typically includes the use of corticosteroids and immunosuppression.


Complications include glomerulonephritis and vasculitis.


The prognosis of this condition is typically poor and can result in end organ damage.

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