Chronic Myeloid Leukaemia

Chronic Myeloid Leukaemia

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Chronic myeloid leukaemia (CML) is a cancer of white blood cells that is characterized by the uncontrolled growth of myeloid cells in the bone marrow.

This uncontrolled growth leads to myeloid cells crowding out the bone marrow and interfering with the production of normal blood cells such as platelets, erythrocytes and neutrophils.

In addition to crowding out the bone marrow, the abnormal myeloid cells spill into the peripheral blood. This is reflected in the full blood count which demonstrates abnormally raised levels of mature granulocytes (neutrophils, basophils and eosinophils).



CML was the first malignancy to be linked directly to a clear chromosomal abnormality.

This abnormality involves a translocation between parts of chromosome 9 and 22, which leads to the formation of the so-called Philadelphia chromosome.

As a result, a gene contained on chromosome 22 called BCR fuses with a gene on chromosome 9 known as ABL. This creates a hybrid gene known as BCR-ABL.

BCR-ABL can add phosphates to tyrosine residues (a tyrosine kinase) and this allows the gene to activate a cascade of proteins that control the cell cycle, speeding up cell division.

In addition, the BCR-ABL protein inhibits DNA repair, causing genomic instability and making the cell more susceptible to developing further genetic abnormalities.

These two mechanisms (speeding cell division and inhibiting DNA repair) lead to the development of chronic myeloid leukaemia.

Clinical features


CML is often asymptomatic upon diagnosis and may present incidentally with an elevated white blood cell count on a full blood count.

Typical symptoms (if present) of CML include:

  • Upper abdominal pain due to hepatosplenomegaly
  • Poor appetite due to enlarged spleen
  • Low-grade fever/night sweats
  • Gout due to increased cell turnover
  • Increased susceptibility to infections due to decreased functional immune cells
  • Shortness of breath/fatigue due to anaemia
  • Easy bruising/petechiae/bleeding due to low platelets
  • Neurological deficits/visual disturbance due to hyperviscosity

Typical clinical findings include pallor, hepatosplenomegaly, and bruising/petechiae.


Laboratory investigations

Relevant laboratory investigations include:

  • Full blood count: leucocytosis, increased eosinophils/basophils/granulocytes, anaemia (normocytic/normochromic)
  • U&E: usually normal
  • Lactate dehydrogenase: may be raised
  • Urate: may be raised due to high cell turnover
  • Peripheral blood film: all stages of granulocyte maturation noted, similar to a bone marrow aspirate

Bone marrow aspirate

Bone marrow aspiration is necessary to stage disease (determine chronic vs accelerated vs blast crisis) and confirm diagnosis (detect the Philadelphia chromosome). The gold standard of diagnosis is the detection of the Philadelphia chromosome, which is present in 95% of people with CML. Methods for identifying the Philadelphia chromosome include FISH (fluorescent in-situ hybridisation) and PCR for the BCR-ABL gene.

Phases of CML

The World Health Organisation (WHO) has developed criteria to define the various stages of CML.¹

Chronic phase

Approximately 85% of patients with CML are in the chronic phase at the time of diagnosis.² During this phase, patients are usually asymptomatic or have only mild symptoms of fatigue or abdominal fullness. The duration of the chronic phase is variable and without treatment, the disease will usually progress to the accelerated phase due to the accumulation of genetic mutations in addition to the BCR-ABL gene.²

Accelerated phase

A patient is said to be in the accelerated phase when any of the following are present:

  • 10 -19% myeloblasts in the blood or bone marrow
  • >20% basophils in the blood or bone marrow
  • Platelet count <100,000, unrelated to therapy
  • Platelet count >1,000,000, unresponsive to therapy
  • Cytogenetic evolution with new abnormalities in addition to the Philadelphia chromosome
  • Increasing splenomegaly or white blood cell count, unresponsive to therapy

This phase is significant as it is a sign that the disease is progressing and that a blast crisis is imminent.²

Blast crisis

Blast crisis is the final phase in the evolution of CML and behaves like acute leukaemia, with rapid progression and short survival.

Blast Crisis

Blast crisis is diagnosed when a patient with CML meets any of the following criteria:

  • More than 20% myeloblasts or lymphoblasts in the blood or bone marrow
  • Large clusters of blasts in the bone marrow on biopsy
  • Development of a chloroma (a solid focus of leukaemia outside the bone marrow)


Tyrosine Kinase Inhibitors

Tyrosine kinase inhibitors target BCR-ABL to inhibit the proliferation of malignant cells by blocking the gene's ability to phosphorylate a tyrosine. Imatinib is a first-generation tyrosine kinase inhibitor and is typically the first line of treatment. Other options include second-generation drugs such as nilotinib and dasatinib.

Bone Marrow Transplantation

Bone marrow transplantation may be considered for those who do not respond to drug treatments. This is usually limited to younger, healthy patients due to its associated risks, including death, and offers the potential of a cure.


  1. Vardiman J, Harris N, Brunning R (2002). The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 100 (7): 2292–302. Available from: LINK
  2. Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era”. Hematology Am Soc Hematol Educ Program 2006: 240–5.

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